Allergic asthma is the display of asthma symptoms as a part of an allergic reaction. Inadvertent inhalation of allergens or ingestion of food proteins can trigger some people’s immune system to overreact and IgE to bind to mast cells. IgE then causes the mast cells to release chemicals known as inflammatory mediators. These are responsible for the swelling that often accompanies allergic reactions and includes histamine, leukotriene, and prostaglandin.
All allergic reactions involve the same type of antibody. Immunoglobulin E is the antibody whose purpose is to seek out and recognize cancer cells. It was suggested that it plays a role in fighting off parasites, but this has yet to be proven. It is the IgE that overreacts to the normally harmless substances, binds to the mast cells, and causes it to release the inflammatory mediators. Allerg is defined as a disorder of the body's immune system. IgE mistakes substances for a potential threat and reacts in a way that harms the body even more.
Pharmaceuticals have considered blocking the activities of the antibody IgE. In 2003, a medicine named Omalizumab was approved for use against allergic asthma. It is also called “Anti-IgE”. This drug is administered subcutaneously every 2 or 4 weeks. It got its nickname because Omalizumab binds free IgE to keep them from producing an allergic reaction.
Though expensive, Omalizumab is suggested to asthmatics that have moderate to severe persistent allergic asthma that cannot be kept under control even with various combinations of asthma medications. It is also recommended for people who have developed complications from inhaled or oral steroid use, or those whose bodies cannot tolerate any asthma medication.
Omalizumab seems promising. But experts worry about the binding of the IgE. Since research suggests that IgE plays an important role in detecting cancer cells, indiscriminate disabling of these antibodies may cause unforeseen problems.
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